Salary Data
Registered Nurse Salary in St. Louis
$74,000
median salary, 10% below the national average
According to Orbit's 2026 salary analysis, the average Registered Nurse salary in St. Louis is $74,000. Salaries range from $56,000 (25th percentile) to $95,000 (75th percentile), adjusted for St. Louis's cost of living.
Salary range
How St. Louis compares
St. Louis, MO
$74,000
Cost of living: 10% below average
National Average
$82,000
St. Louis is $8,000 below
Registered Nurse job market in St. Louis
St. Louis market overview
St. Louis offers one of the most affordable major metro areas in the country, with a strong base in healthcare, financial services, and manufacturing. The region's anchor employers include Boeing, Centene, and Washington University's medical campus. A growing biotech and plant sciences corridor centered on the Cortex Innovation District is attracting new investment and talent.
What drives Registered Nurse salaries
Specialty certification, geographic location, and facility type create the widest salary ranges. ICU, OR, and emergency nurses earn premiums over med surg nurses. Travel nursing contracts can pay 50 to 100% more than permanent positions. Union representation and shift differentials for nights and weekends also impact total pay.
Beyond base salary
Total compensation
Benefits are a major component, typically including health insurance, pension or 403(b) matching, tuition reimbursement, and continuing education credits. Shift differentials add $3 to $8 per hour for nights and weekends. Signing bonuses of $5,000 to $20,000 are common in high demand specialties.
Tax considerations in St. Louis
Missouri's top income tax rate is about 4.8%, and St. Louis City adds a 1% earnings tax. The low base cost of living means your after tax salary still stretches further than in most metros.
Career progression
New graduate RNs start at $58,000 to $72,000, with experienced RNs reaching $80,000 to $100,000 after five years. Nurse practitioners earn $110,000 to $140,000, and CRNAs (nurse anesthetists) can earn $180,000 to $220,000. Nursing management roles offer $95,000 to $140,000 with administrative responsibilities.
Top industries in St. Louis
Negotiating in St. Louis
Emphasize your willingness to work in person at Cortex or the BJC campus. St. Louis employers offer higher packages for candidates who commit to the local innovation hubs.